Ellagic acid,developed as an active ingredient of quasi-drugs, is also one of the well-known inhibitors of tyrosinase. It was confirmed that ellagic acid inhibits tyrosinase dose-dependently and noncompetitively,unlike arbutin. As shown in Figure 7, tyrosinase activity was reduced with decreasing copper concentration, when mushroom-derived tyrosinase,a metalloprotein containing copper, was incubated with ellagic acid.
Since ellagic acid is known to chelate some specific metal ions, it is presumed to react specifically with the copper located at the active site of the tyrosinase molecule. Ellagic acid is a naturally occurring polyphenol, which is found widely
distributed in plants such as tara, green tea, eucalyptus, and geranium. These two active ingredients are examples of natural-origin compounds being used as skin-whitening agents.
Ellagic acid,developed as an active ingredient of quasi-drugs, is also one of the well-known inhibitors of tyrosinase. It was confirmed that ellagic acid inhibits tyrosinase dose-dependently and noncompetitively,unlike arbutin. As shown in Figure 7, tyrosinase activity was reduced with decreasing copper concentration, when mushroom-derived tyrosinase,a metalloprotein containing copper, was incubated with ellagic acid.Since ellagic acid is known to chelate some specific metal ions, it is presumed to react specifically with the copper located at the active site of the tyrosinase molecule. Ellagic acid is a naturally occurring polyphenol, which is found widelydistributed in plants such as tara, green tea, eucalyptus, and geranium. These two active ingredients are examples of natural-origin compounds being used as skin-whitening agents.
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