Dehydroabietic acid (DHA), which is

Dehydroabietic acid (DHA), which is a natural occurring
diterpenic resin acid, has been found to have properties of increasing the inhibition activity of an anticancer drug in various cells, e.g. cervical carcinoma cells, hepatocellular carcinoma cells,
and breast cancer cells, as well as its analogs [7]. Therefore DHA
skeleton was chosen as active pharmacal core to screen for new
potential antitumor compounds by the introduction of various
functional groups [8e11]. In previous work, it has been found that
the introduction of sulfocarbamide on ring B and C [8,12], as well
as in carboxylic acid group of DHA showed improved antitumor
activity [9]. Furthermore, aminophosphonates groups are able to
better improve the antitumor activity and many aminophosphonates
derivatives have shown good inhibition activities
against human tumors [13e16]. However, to the best of our
knowledge, the studies on the synthesis, antitumor activities and
apoptosis-inducing effects of thiourea a-aminophosphonate derivatives
derivated from DHA have not been explored. So in this
paper, functional groups thiourea and a-aminophosphonate
groups were rationally designed and introduced to the carboxylic
acid part of DHA skeleton to offer a series of novel thiourea aaminophosphonate
derivatives containing DHA. Their cytotoxicity
in vitro against four selected tumor cell lines were evaluated.
Results showed that the target compounds can inhibit proliferation
of these four tumor cell lines at moderate to high rates.
Preliminary investigation on the mode of action of compound 5f
found that it can effectively induce cell apoptosis in A549 cells.

結果 (中文) 1:

脱氢枞酸 (DHA)，这是自然的发生diterpenic 树脂酸，已被发现有增加的抑菌活性，在各种细胞，如子宫颈癌细胞、 肝癌细胞，一种抗癌药物的属性乳腺癌细胞，以及和其类似物 [7]。因此 DHA骨架被评为积极药物核心新屏幕通过介绍各种潜在抗肿瘤化合物官能团 [8e11]。在以往的工作，它已经发现，B 和 C 环上的硫脲概论 [8,12]，在羧酸的 DHA 显示组改善抗肿瘤活动 [9]。此外，腈类化合物群体都能够到更好地提高抗肿瘤活性和许多腈类化合物衍生品有较好抑制作用活动对人类肿瘤 [13e16]。然而，到最好的我们知识、 合成、 抗肿瘤活性研究和一 aminophosphonate 硫脲的诱导凋亡作用从 DHA 推导未被探索。所以在这纸、 官能团硫脲和一个 aminophosphonate合理设计并介绍给的羧基组了酸的 DHA 骨骼能够提供一系列的新型硫脲 aaminophosphonate 的一部分含 DHA 的衍生物。其细胞毒性体外抗四选的肿瘤细胞系进行了评价。结果表明，目标化合物可以抑制扩散这些四个肿瘤细胞系在缓和到较高。化合物 5f 行动的模式的初步研究发现它可以有效地诱导 A549 细胞的细胞凋亡。

結果 (中文) 3:

脱氢枞酸（DHA），这是一个自然发生的
二萜树脂酸，已发现有增加各种细胞的抗癌药物的抑制活性的特性，例如宫颈癌细胞、肝癌细胞，
和乳腺癌细胞，以及其类似物[ 7 ]。因此DHA
骨架作为活性药物筛选新的
核心潜在的抗肿瘤化合物的各种
官能团[ 8e11 ]介绍。在以往的工作中，已发现
引入环B和C [ 12 ]硫脲，以及
在DHA羧酸组表现出改进的抗肿瘤
活动[ 9 ]。此外，氨基膦酸酯基团能够
更好的完善和许多
氨基膦酸盐的抗肿瘤活性衍生物具有良好的抑制活性
对人类肿瘤[ 13e16 ]。然而，据我们
知识，对合成的研究，抗肿瘤活性和诱导细胞凋亡的
硫脲α-氨基膦酸酯衍生物的影响
衍生DHA尚未探究。所以在这
纸、官能团硫脲和α-氨基膦酸酯
组设计合理并介绍了DHA骨架羧酸
酸部分提供了一系列新的硫脲衍生物aaminophosphonate
含有DHA。对四个选定的肿瘤细胞株进行体外细胞毒性实验，结果表明，目标化合物能抑制四个肿瘤细胞株增殖，在中等至高的水平。对化合物5F
行动模式的初步调查发现，它能有效地诱导人肺癌A549细胞凋亡。