The success of antiretroviral thera

The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible. For patients who are motivated to take therapy and who have access to lifelong treatment, AIDS-related illnesses are no longer the primary threat, but a new set of HIV-associated complications have emerged, resulting in a novel chronic disease that for many will span several decades of life. Treatment does not fully restore immune health; as a result, several infl ammation-associated or immunodefi ciency complications such as cardiovascular disease and cancer are increasing in importance. Cumulative toxic eff ects from exposure to antiretroviral drugs for decades can cause clinically-relevant metabolic disturbances and end-organ damage. Concerns are growing that the multimorbidity associated with HIV disease could aff ect healthy ageing and overwhelm some health-care systems, particularly those in resource-limited regions that have yet to develop a chronic care model fully. In view of the problems inherent in the treatment and care for patients with a chronic disease that might persist for several decades, a global eff ort to identify a cure is now underway

結果 (繁體中文) 2:

抗逆轉錄病毒療法的成功使一些人現在問，愛滋病結束是否可能。對於有動機接受治療和獲得終身治療的患者來說，與愛滋病有關的疾病已不再是主要威脅，而是出現了一系列與愛滋病毒相關的新併發症，導致一種新型的慢性疾病，對許多人來說，這種病將跨越幾十年的生活。治療不能完全恢復免疫健康;因此，一些與腫瘤相關或免疫不均的併發症，如心血管疾病和癌症，其重要性正在增加。數十年來，接觸抗逆轉錄病毒藥物的累積毒性作用可引起臨床相關的代謝紊亂和終器官損傷。人們越來越擔心，與愛滋病毒疾病有關的多種疾病可能導致健康的老齡化，使一些保健系統不堪重負，特別是那些資源有限的地區尚未完全發展慢性護理模式的保健系統。鑒於慢性病患者的治療和護理中固有的問題可能持續幾十年，目前正在進行一項全球有效方法，以確定一種治療方法。

結果 (繁體中文) 3:

抗逆轉錄病毒療法的成功使一些人現在開始質疑愛滋病是否有可能結束。對於那些積極接受治療並獲得終身治療的患者來說，與愛滋病有關的疾病不再是主要威脅，而是出現了一系列新的與愛滋病毒有關的併發症，導致了一種新的慢性疾病，這種疾病將持續幾十年的生命。治療不能完全恢復免疫健康；囙此，一些與注射相關或免疫缺陷的併發症，如心血管疾病和癌症，變得越來越重要。數十年抗逆轉錄病毒藥物的累積毒性作用可導致臨床相關代謝紊亂和終末器官損傷。人們越來越擔心，與愛滋病毒有關的多發病率可能會影響健康老齡化，並使一些保健系統，特別是那些資源有限的地區，尚未完全建立一個慢性保健模式。鑒於慢性病患者的治療和護理中固有的問題可能會持續幾十年，現時正在進行一項全球努力來確定一種治療方法