The significant elevation in BP in

The significant elevation in BP in rats treated with glucose, with or without corn oil, for 5 wk is in agreement with previous studies that found that glucose or fructose feeding induced HTN in rats. The present study showed that the basal superoxide anion production from aorta was increased in glucose corn oil or glucose-treated rats. A similar enhancement of basal superoxide anion production was reported in aortas from insulin-resistant glucose or fructose-fed rats . The present study showed that NADPH oxidase activity from aorta increased in glucose corn oil–or glucose-fed rats. These results are in agreement with previous studies that suggested that the superoxide anion production in the aorta was mediated through activation of NADH/NADPH oxidase in insulin-resistant and in hypertensive angiotensin-treated rats . Thus, the present study may suggest an involvement of the vascular oxidative stress in the elevation of systolic arterial pressure induced by chronic glucose, with or without corn oil intake.

結果 (繁體中文) 1:

在 BP 大鼠葡萄糖，有或沒有玉米油，治療 5 周齡顯著升高是與以前的研究發現，葡萄糖或果糖誘導鼠 HTN。本研究表明，從主動脈產生基部的超氧陰離子增高玉米油葡萄糖或葡萄糖治療大鼠。基部的超氧陰離子生產類似增強報導從胰島素抵抗葡萄糖或果糖的老鼠的主動脈。本研究表明從主動脈增加葡萄糖玉米油中那 NADPH 氧化酶活性 — — 或葡萄糖喂大鼠。這些結果與以前的研究表明，主動脈產生超氧陰離子介導通過啟動的 NADH/NADPH 氧化酶在胰島素抵抗和高血壓血管緊張素治療大鼠。因此，本研究可能參與血管氧化應激誘導慢性葡萄糖，有或沒有玉米油攝入的收縮期動脈壓的海拔。

結果 (繁體中文) 2:

在血壓顯著高程與葡萄糖處理的，有或沒有玉米油大鼠，5週是在與先前的研究，發現在大鼠中葡萄糖或果糖饋送誘發高血壓的協議。本研究表明，從主動脈基底超氧陰離子生產葡萄糖玉米油或葡萄糖處理的大鼠增加。基礎超氧陰離子生產類似的增強報導，從胰島素抵抗葡萄糖或果糖餵養大鼠主動脈。本研究表明，從主動脈NADPH氧化酶活性在葡萄糖玉米油或葡萄糖餵養大鼠增加。這些結果與以前的研究表明，在超氧化物陰離子產生的主動脈是通過在胰島素抵抗的NADH / NADPH氧化酶的激活和高血壓血管緊張素處理的大鼠介導的協議。因此，本研究可以建議血管氧化應激在慢性葡萄糖，有或沒有玉米油攝入誘導收縮期動脈壓的升高的參與。