It is not unusual for UrC to be confused with primary bladder dome tumors, though UrC exhibit distinct pathologic and clinical differences from bladder carcinomas [68]. Most bladder carcinomas are urothelial carcinoma and present as non-invasive papillary urothelial carcinomas that do not invade the muscular wall [68,69]. In contrast, the majority of UrC are adenocarcinomas that usually produce abundant extracellular mucin and exhibit focal signet ring cell features. Also, UrC frequently involves the muscularis propria and perivesical soft tissues, possess a sharp delineation from the bladder surface urothelium, and lack papillary urothelial carcinoma or urothelial carcinoma in situ [68,69]. Further, UrC develop at a relatively younger age compared to bladder carcinomas, with less male predominance. Although the prognosis of UrC is poor, urachal neoplasms tend to have a better prognosis relative to bladder urothelial carcinoma of similar stages [68,69].The risk factors for UrC, specifically urachal adenocarcinomas, remain unclear. Patients with urachal tumors typically experience poor outcomes [[67], [68], [69]]. The extraperitoneal location allows for neoplasm to remain quiescent, perpetuating delays in symptoms. Naturally, this causes delays in UrC diagnosis until the tumor cells become symptomatic at more advanced stages [5]. Table 1 summarizes the two prevailing staging systems used grading urachal cancers.
It is not unusual for UrC to be confused with primary bladder dome tumors, though UrC exhibit distinct pathologic and clinical differences from bladder carcinomas [68]. Most bladder carcinomas are urothelial carcinoma and present as non-invasive papillary urothelial carcinomas that do not invade the muscular wall [68,69]. In contrast, the majority of UrC are adenocarcinomas that usually produce abundant extracellular mucin and exhibit focal signet ring cell features. Also, UrC frequently involves the muscularis propria and perivesical soft tissues, possess a sharp delineation from the bladder surface urothelium, and lack papillary urothelial carcinoma or urothelial carcinoma in situ [68,69]. Further, UrC develop at a relatively younger age compared to bladder carcinomas, with less male predominance. Although the prognosis of UrC is poor, urachal neoplasms tend to have a better prognosis relative to bladder urothelial carcinoma of similar stages [68,69].<br><br>風險因素URC,尤其是臍尿管腺癌,目前仍不清楚。患者臍尿管腫瘤通常會經歷不良後果[67],[68],[69]]。腹膜外位置允許腫瘤保持靜止,症狀延續延遲。自然地,這將導致在URC延誤診斷直至腫瘤細胞在更晚期階段[5]成為症狀。表1總結了兩種流行的分級系統中使用的分級臍尿管癌症。
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