Using a molecular genetic approach,

Using a molecular genetic approach, we try to
confirm the molecular alterations of inverted papilloma and
clarify its status as a putative precursor lesion of sinonasal
squamous cell carcinoma. To better understand its genetics,
we investigated the immunohistochemical protein expres-
sion patterns of cell-cycle-regulators p53, p63, p21, p27
and proliferation marker Ki-67 in 22 inverted papilloma
and 9 squamous cell carcinoma of the sinonasal tract.
Significantly elevated levels of p53 and p63 in squamous
cell carcinoma of sinonasal tract compared with inverted
papilloma were revealed. Ki-67-stained neoplastic cell
nuclei were found in a significantly higher percentage of
squamous cell carcinoma of sinonasal tract than in inverted
papilloma, whereas no variation of p21 and p27 expression
was identified. This work first examined the immunohis-
tochemical overexpression of p63 in sinonasal inverted
papilloma and squamous cell carcinoma. In conclusion,
this is a first study shedding light on the expression of p63
in tumors of paranasal sinuses.

結果 (中文) 1:

我们使用分子遗传学方法，尝试到确认的分子改变乳头状和作为公认的前驱病变的鼻腔鼻窦澄清其地位鳞状细胞癌。为了更好地理解其遗传学我们研究了免疫组化蛋白表达-细胞周期调节 p53、 p63、 p21 和 p27 的中港合资模式和增殖标记 Ki 67 22 倒立乳头状瘤和 9 鼻窦鳞状细胞癌。P53、 p63 在鳞状上皮的水平显著升高鼻窦相比细胞癌倒揭示了乳头状瘤。Ki 67 染色肿瘤细胞核被发现在比例显著较高的鳞状细胞癌的鼻窦比在颠倒乳头状瘤、 而没有 p21 和 p27 表达的变化被确定。这项工作首先检查免疫组化-p63 在鼻腔、 鼻窦组织过表达乳头状瘤及鳞状细胞癌。总之，这是首次研究 p63 曝光在鼻窦肿瘤。

結果 (中文) 3:

使用分子遗传方法，我们试图确认内翻性乳头状瘤和乳头状瘤的分子改变明确其作为一个假定的鼻腔鼻窦癌前病变状态鳞状细胞癌。为了更好地了解它的遗传学，我们研究了免疫组化表达—细胞周期调控因子p53、p21的表达方式，表达p63和Ki-67在内翻性乳头状瘤229鳞状细胞癌中鼻道。在鳞状上皮p53和p63水平显著升高对鼻窦癌相比，倒乳头状瘤。Ki-67的染色肿瘤细胞核被发现在一个显着更高的百分比鳞状细胞癌鼻窦比倒乳头状瘤，而没有变化，p21和p27的表达被确定。本文首先研究了免疫组—化学表达p63蛋白在鼻腔鼻窦内翻乳头状瘤与鳞状细胞癌。结论，这是第一次研究揭示p63的表达在副鼻窦肿瘤。