IInterestingly induction of ERBB2/HER2 expression has been shown to increase MCL1 mRNA levels in MCF-7 cells, perhaps explaining the high level of MCL-1 protein we find in ERBB2/HER2-positive disease and it is possible that while not prognostic, these tumours could still depend on MCL-1 for survival as was indeed observed in a very recent study from the Lindeman group.