The diagnostic workup of osteomyelitis and soft-tissue infections can be challenging, because the symptoms are often nonspecific. This issue exists both in the pediatric population, where hematogenous osteomyelitis is more common, and also in older patients, where osteomyelitis complicates up to one-third of diabetic foot lesions as the result of direct spread of infection. Early diagnosis of osteomyelitis is important, because antibiotic therapy can be curative and may prevent amputation. Conventional imaging modalities, such as radiography, ultrasound, CT, and MRI, are usually first-line imaging options for diagnostic management of osseous infections. However, these methods sometimes fail to appropriately localize or confirm infection.