Type I- Isolated monoclonal immunoglobulin, generally IgM or IgG, is rarely seen in IgA.- No exists rheumatoid factor activity.- Cryoglobulin >5 mg/mL.- Occurs in multiple myeloma and monoclonal gammopathy associated with the lymphoproliferative disorder.• Type II- Mixture of monoclonal IgM and polyclonal IgG. - Exists in rheumatoid factor (IgM) activity.- Cryoglobulin 1 mg/mL.