There is a high prevalence of polypharmacy in home care, elderly patient. These patient may lead to drug safety problems, such as over sedation, weakness, cognitive impairment , urine incontinence and many more adverse effects. Geriatrician has came to be aware of this problem and measurements such as medication reconciliation clinic or comprehensive geriatric assessment (CGA) during hospitalization provide a chance to reduce unnecessary medications. Despite these measurements, there are still barriers to break to keep the patient and the family feeling comfortable to avoid polypharmacy.