3.2.1. Protection against Edema
The inhibitory activity of the studied compounds on car-rageenan-induced rat’s paw edema was carried out ac-cording to the method of Winter et al. [19,20]. Groups of adult male albino rats (150 - 180 gm), each of 8 animals were orally dosed with the test compounds at a dose level of 2.5 and 5 mg/kg an hour before carrageenan challenge. Foot paw edema was induced by sub planter injection of 0.05ml of 1% suspension of carrageenin in saline into the planter tissue of one hind paw. An equal volume of saline was injected to the other hind paw and served as control. Four hours after drug administration the animal was de-capitated, blood was collected and the paws were rapidly excised.