The exact function of HsClpP in cancer pathology is not well understood, although the expression of HsClpP has been shown to be generally upregulated in solid cancers of multiple organs or tissues, such as lung, stomach, liver, thyroid, bladder, breast, ovary, prostate, testis, and the central nervous system. The level of HsClpP expression is also increased significantly in the nonsolid acute myeloid leukemia. Furthermore, immunohistochemistry (IHC) analysis of patient tissue samples covering 17 cancer types has shown moderate to high levels of HsClpP expression in malignant cells compared to normal ones.