As the psychiatrist Barry Reisberg frst observed twenty years ago, the decline of an Alzhcimer's patient mirrors inreverse the neurological development of a child. The earliest capacities a child develops--raising the head (at one to three months), smiling (two to four months), sitting up unassisted (six to ten months)--are the last capacities an Alzheimer's patient loses. Brain development in a growingchild is consolidated through a process called myelinization, wherein the axonal connections among neurons are gradually strengthened by sheathings of the fatty substance myelin. Apparently, since the last regions of the child's brain to mature remain the least myelinated, they're the regions mostvulnerable to the insult of Alzheimer's. 'The hippocampus, which procesees short- term memories into long-term, is very slow to myelinine. This is why we're unable to form permanent episodic memories before the age of three or four, and why the hippocampus is where the plaques and tangles of Alzheimer's first appear. Hence the ghostly apparition of themiddle-stage patient who continues to be able to walk and feed herself even as she remembers nothing from hour tohour. The inner child isn't inner anymorc. Neurologically speaking, we're looking at a one-year-old.
As the psychiatrist Barry Reisberg frst observed twenty years ago, the decline of an Alzhcimer's patient mirrors in<br>reverse the neurological development of a child. The earliest capacities a child develops--raising the head (at one to three months), smiling (two to four months), sitting up unassisted (six to ten months)--are the last capacities an Alzheimer's patient loses. Brain development in a growing<br>child is consolidated through a process called myelinization, wherein the axonal connections among neurons are gradually strengthened by sheathings of the fatty substance myelin. Apparently, since the last regions of the child's brain to mature remain the least myelinated, they're the regions most<br>易受阿爾茨海默氏症的侮辱。“海馬,這procesees短期記憶轉化為長期,非常慢myelinine。這就是為什麼我們無法形成博<br>三四歲之前新界東北情節記憶,為什麼海馬正是老年癡呆症的斑塊和纏結首先出現。因此,幽靈般的幻影<br>中段病人誰仍然能夠行走和飼料她甚至為她記得從小時沒什麼<br>小時。內孩子是不是內anymorc。神經學上來講,我們正在尋找一個一歲。
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