FDG is by far the most common radiotracer used in PET/CT of bone and soft-tissue infections, with diabetic foot being the most commonly studied clinical scenario. This is more challenging diagnostically than other types of osteomyelitis, because diabetic neuropathy may lead to the development of neuropathic osteoarthropathy (Charcot joint), which can mimic osteomyelitis clinically and on radiographic and MRI studies [10]. Table 1 summarizes clinical studies over the past 2 decades on the value of FDG PET/CT for acute and subacute bone and soft-tissue infections. Overall, these studies have confirmed the value of FDG PET/CT in patients with suspected osteomyelitis, including diagnostic workup of patients with fever of unknown origin (Fig. 2). They also confirmed the ability of FDG PET/CT to differentiate osteomyelitis from its main differential considerations, including soft-tissue infections and neuropathic osteoarthropathy [3, 10–15]