Metal-organic frameworks (MOFs) are a class of well-ordered crystalline coordination polymers possessing many attractive characteristics and potential applications in various fields including materials, biological, energy and environmental areas (Alkordi et al. 2008; Furukawa et al. 2013; Guo et al. 2014; Kundu et al. 2014). MOFs have huge amount of metallic ions, yielding high electrochemical signals while undergoing electrochemical detection. MOFs and MOFs-derived hybrid materials are well known for their electrochemical applications (Wu et al. 2018; Yang et al. 2018; Zhang et al. 2018) owing to its permanent porous structure, presence of uniform conductive carbon scaffold, and ultra-small active materials. This type of construction further enables MOFs to serve as a potential candidate for self-supported electrodes (Zhang et al. 2017). In recent days MOFs are being used as electrode materials which are important in biochemistry for developing high sensitive electrochemical methods for potential detection of trace amount of biological compounds. The superior properties of MOFs such as high surface areas, various pore sizes, availability of active sites, and controlled surface properties enable them ideal biosensor for electrochemical reactions (Torrisi et al. 2013; Xiong et al. 2014).