There is a high prevalence of polypharmacy in home care, elderly patient. These patient may lead to drug safety problems, such as over sedation, weakness, cognitive impairment , urine incontinence and many more adverse effects. Geriatrician has came to be awarof this problem and measurements such as medication reconciliation clinic or comprehensive geriatric assessment (CGA) during hospitalization provide a chance to reduce unnecessary medications. Despite these measurements, there are still barriers to break to keep the patient and the family feeling comfortable to avoid polypharmacy.