Sites treated with the straight hand piece had fainterythema at lower fluences and superficial crustingand erythema at the higher fluences 24 hoursafter treatment.• Site treated with the focus array demonstrated milderythema lasting approximately 24 hours.Conclusion:• Significant absorption of laser light by melaninleading to injury to collateral epidermal cells.• The extent of injured sites appears to be both doseand pigmentation dependent as reflected by skintyping, tanning, and Melanin Index (MI).• The diffractive lens array light delivery modalityappears to selectively damage localized regionsin the epidermis with a good safety and sideeffect profile.