Melanin plays an important role in protection the skin
against ultraviolet light injury and is responsible for
skin color. However, overproduction and accumulation
of melanin result in several skin disorders including
freckles, melasma, age spots and other hyperpigmentation
syndrome [1]. Tyrosinase (monophenol, L-dihydroxyphenylalanine
(L-DOPA): oxygen oxidoreductase EC
1.14.18.1) is the key enzyme in the first two steps of
melanin biosynthesis, in which L-tyrosine is hydroxylated
to L-DOPA (o-diphenol product), and L-DOPA is further
oxidized into the corresponding o-quinone [2]. It has
been reported that microphthalmia-associated transcriotion