Because patients with SCA experience various types and severities of psychotic, depressive, and/or manic symptoms, understanding the extent and timing of treatment effects on each of these symptom groups and providing insights into the use of concomitant therapies are important for clinical decision-making. This pooled analysis of two large registration trials in acutely ex- acerbated subjects with SCA evaluated the pattern and timing of onset of pali ER treatment effects for the three primary SCA symptom domains: psychosis, depression, and mania.