Primary outcome after 2 years is cognitive performance measured by a comprehensiveneuropsychological test battery. The 2-year intervention was finalized in February 2014.Results: We found a significant beneficial intervention effect on overall cognitive performance. Thebeneficial effect was seen on each cognitive domain: memory; executive function, and psychomotorspeed. Drop-out rate was only 11%, and participants’ experiences were very positive.Conclusions: This is the first large RCT showing that it is possible to prevent cognitive decline using amultidomain intervention among older at-risk individuals. These results highlight the value of thefeasible and novel multidomain approach that is effective for several cognitive domains.