4. DiscussionPhotoaging is characte

4. DiscussionPhotoaging is characterized by epidermal atrophy, which has been linked to ultraviolet-induced damage on the stem cells of the basal layer and the hair follicle .The study product significantly increased epidermal thickness, and this thickening was mediated by the promotion of the epidermal cell proliferation, as it has been demonstrated by the significant increase in the expression of the marker of cell proliferation Ki67 in the basal layer. This stimulus may be attributed either to the retinoid component of the product, as previously described in the literature , or to IFC-CAF,which has been reported to facilitate the in vitro proliferation, differentiation, and migration of keratinocytes

結果 (繁體中文) 1:

4.討論
光老化的特徵在於表皮萎縮，這已被鏈接到紫外線引起的損傷的基底層和毛囊。研究產品顯著增加表皮厚度的幹細胞，並且該增厚是由促進的介導表皮細胞增殖，因為已經通過在細胞增殖的Ki67的基底層的標誌物的表達的增加顯著證明。這種刺激可以或者歸因於產品的類視黃醇組分，如先前所描述在文獻中，或者到IFC-CAF，已經報導，以促進在體外的增殖，分化，細胞和角質細胞的遷移

結果 (繁體中文) 2:

4. 討論
光老化的特點是表皮萎縮，它與紫外對基底層和毛囊的幹細胞的損害有關。研究產物顯著增加表皮厚度，這種增厚通過促進表皮細胞增殖得到調節，正如細胞增殖標記表達的顯著增加所證明的基67在基底層。這種刺激可以歸因於產品的視網膜成分，如文獻前面所述，或IFC-CAF，已報告，以促進角質細胞的體外增殖，分化和遷移

結果 (繁體中文) 3:

四。討論
光老化的特點是表皮萎縮，這與紫外線對基底層幹細胞和毛囊的損傷有關，研究產品顯著增加了表皮厚度，這種增厚是通過促進表皮細胞增殖而介導的，細胞增殖標誌物Ki67在基底層的表達顯著增加。如前所述，這種刺激可能歸因於產品中的維甲酸成分，也可能歸因於IFC-CAF，據報導IFC-CAF促進角質形成細胞的體外增殖、分化和遷移