To our knowledge, no study to date has examined the effects of argan oil on two important cardiovascular risk factors conjointly, namely HTN and IR induced by a high-carbohydrate diet. Because argan oil is now available as a consumable food, it is important to elucidate the mechanism by which it can prevent or improve cardiovascular risk factors. Therefore, the present study was designed to investigate whether a chronic 5-wk treatment with argan oil can improve arterial HTN, hyperglycemia, hyperinsulinemia, and IR, and increase basal superoxide anion production and NADPH oxidase activity at the vascular level in hypertensive insulin-resistant rats.