Accurate estimations of manual arm strength (MAS) are crucial in the evaluation of occupational force demands relative to population capacity. Most current strength predictions assume force application with a vertically oriented handle, but it is unknown how uni-manual force capability changes as a function of handle orientation and hand location. This study evaluated the effect of handle orientation on MAS throughout the reach envelope. Fifteen female participants exerted maximum forces in six directions (i.e. superior, inferior, anterior, posterior, medial, lateral), at five different hand locations, and MAS was measured with the handle oriented at 0° (i.e. horizontal), 45°, 90° (i.e. vertical) and 135°. Handle orientation affected MAS in all but the anterior exertion direction, with significant interactions between hand location and grip orientation existing for the superior and inferior directions. These results suggest that handle orientation is important to consider in future predictive models of manual arm strength.