Our current medical system often attempts to circumvent an acute psychoactive drug reaction, but that effect is integral to the modality of psychedelic healing. For example, Johnson & Johnson’s newly patented, FDA-approved esketamine nasal spray Spravato lists dissociation as a “serious side effect.” While low-dose ketamine arguably does provide relief from depression on a biochemical level, the dissociative effect itself is one of the main aspects of the ketamine experience that is leveraged therapeutically by providers who intentionally use a higher dose psychedelic range.