NGS methods produce many “runs” of the same DNA sequence fragments, each linked on both ends with adapters to enhance sequencing methodsfragments are sequenced many times and computing tools are used to align the fragments by like endsthis allows for far greater depth of coverage of the sequence than the Sanger method“Coverage” is a term that relates how many times each nucleotide is sequenced in a genomegreat depth of coverage decreases the likelihood of false sequence data being generated by a random mistake in the polymerase activity during the PCR portion of the process