Half of the tattoo was treated with the best toleratedfluence based on test spots; and the other half wastreated with escalating doses over the four treat-ments to a max fluence based on clinical response,not exceeding 4.1J/cm2.• Subjects received 4 treatments at 1 monthintervals and were evaluated 1 month after theirlast treatment.• A subset of subjects consented to biopsies 24 hourspost their 1st test spot on normal skin.