Maintenance of genome stability is

Maintenance of genome stability is of crucial importance to cellular and organismal survival. Double-strand breaks (DSBs) are highly toxic legions that can lead to loss or amplification of genetic information, chromosomal translocations, neoplastic transformation and cell death1. To counteract these lesions and mitigate their consequences, cells activate a complex network of repair and signaling pathways, collectively known as the DNA damage response (DDR)2. The DDR coordinates diverse processes such as cell-cycle checkpoint signaling cascades, localized chromatin modifications and functions of multiprotein DNA repair complexes. Individuals born with a defective DDR have syndromes with diverse sequelae, including cancer
predisposition, neurodegeneration and immunodeficiency.

結果 (繁體中文) 2:

基因組維穩是對細胞和有機體的生存至關重要。雙鏈斷裂（DSB的）有劇毒軍團，可導致損失或遺傳信息，染色體易位，致瘤性轉化和細胞death1擴增。為了抵消這些病變並減輕其後果，細胞激活一個複雜的網絡修理和信號通路的，統稱為DNA損傷響應（DDR）2。在DDR協調不同的過程，如細胞週期檢驗點信號級聯反應，局部染色質修飾和多蛋白DNA修復複合體的功能。天生有缺陷的DDR個人有證有不同的後遺症，包括癌症
易感性，神經退行性疾病和免疫缺陷。

結果 (繁體中文) 3:

維持基因組的穩定的細胞和有機體的生存至關重要。雙鏈斷裂（DSBs）是劇毒的軍團，可以導致損失或遺傳資訊，放大的染色體易位，腫瘤轉化和細胞死亡。以抵消這些病變和減輕其後果，細胞啟動修復訊號通路的複雜網路，統稱為DNA損傷反應（DDR）2。DDR座標不同的過程，如細胞週期檢查點的訊號級聯反應，局部染色質修飾和功能複合蛋白DNA修復複合物。個人與生俱來的缺陷有不同證候DDR後遺症，包括癌症
傾向，神經退行性疾病和免疫缺陷。