Injuries to the inner meniscal regions impair normal function and poor vascularization limits their healing response. Partial meniscectomy for non-healing injuries can provide relief of symptoms but is associated with greater prevalence of radiographic osteoarthritis (OA) in the long term. A promising strategy to mitigate the development of OA is tissue engineering (TE) of meniscus replacements.Complete TE meniscus replacements can be generated with the use of porous scaffolds infiltrated with cells expressing a meniscus extracellular matrix (ECM)-forming phenotype. These scaffolds are designed to provide structural support and serve as a template for de novo tissue formation.