Antenatal milk anti-influenza antib

Antenatal milk anti-influenza antibodies may provide additional protection to newborns until they are able to produce their own antibodies. To evaluate the relative abundance of milk, we studied the antibodies specific to influenza A in feeds and gastric contents and stools from preterm infants fed mother's own breast milk (MBM) and donor breast milk (DBM). Feed (MBM or DBM) and gastric contents (MBM or DBM at 1 h post-ingestion) and stool samples (MBM/DBM at 24 h post-ingestion) were collected, respectively, from 20 preterm (26-36 weeks gestational age) mother-infant pairs at 8-9 days and 21-22 days of postnatal age. Samples were analyzed via ELISA for anti-H1N1 hemagglutinin (anti-H1N1 HA) and anti-H3N2 neuraminidase (anti-H3N2 NA) specificity across immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) isotypes. The relative abundance of influenza A-specific IgA in feeds and gastric contents were higher in MBM than DBM at 8-9 days of postnatal age but did not differ at 21-22 days. Anti-influenza A-specific IgM was higher in MBM than in DBM at both postnatal times in feed and gastric samples. At both postnatal times, anti-influenza A-specific IgG was higher in MBM than DBM but did not differ in gastric contents. Gastric digestion reduced anti-H3N2 NA IgG from MBM at 21-22 days and from DBM at 8-9 days of lactation, whereas other anti-influenza A antibodies were not digested at either postnatal times. Supplementation of anti-influenza A-specific antibodies in DBM may help reduce the risk of influenza virus infection. However, the effective antibody dose required to induce a significant protective effect remains unknown.

結果 (繁體中文) 1:

產前牛奶抗流感抗體，可以提供給新生兒額外的保護，直到他們能夠自己製作的抗體。為了評價牛奶的相對豐度，我們所研究的特異性的抗體甲型流感在飼料和胃內容物和糞便美聯儲母親自己的乳汁（MBM）和捐贈母乳（DBM）早產兒。進料（MBM或DBM）和胃內容物（MBM或DBM在1小時後攝取）和糞便樣品（MBM / DBM在24小時後攝取）收集，分別從20早產（26-36孕週）在8-9天對母嬰和產後日齡21-22天。將樣品通過ELISA分析抗H1N1血凝素（抗HA H1N1）和抗H3N2神經氨酸酶跨越免疫球蛋白A（IgA的）（抗H3N2 NA）的特異性，免疫球蛋白M（IgM抗體），和免疫球蛋白G（IgG）的同種型。A-流感特異性的IgA飼料和胃內容物的相對豐度肉骨粉均高於DBM在產後日齡8-9天，但在21-22天沒有差異。抗流感特異性IgM是MBM比DBM高在飼料和胃的樣本都產後倍。在這兩個產後倍，抗A型流感病毒特異性IgG肉骨粉比DBM是高，但在胃內容物沒有差別。胃消化在21-22天，從DBM從MBM降低的抗H3N2 NA的IgG在哺乳的8-9天，而其它的抗流感A抗體沒有在任產後倍消化。在DBM抗流感特異性抗體的補充可能有助於減少流感病毒感染的風險。然而，以誘導顯著保護作用所需的有效劑量的抗體仍然是未知的。

結果 (繁體中文) 2:

Ông già đã đối xử với cậu bé xấu

結果 (繁體中文) 3:

產前母乳抗流感抗體可以為新生兒提供額外的保護，直到他們能够產生自己的抗體。為了評估母乳的相對豐度，我們研究了餵食母乳（MBM）和捐贈者母乳（DBM）的早產兒的飼料、胃內容物和糞便中對甲型流感的特异性抗體。分別從20對8-9日齡和21-22日齡早產兒（孕26-36周）中採集飼料（MBM或DBM）和胃內容物（攝食後1小時的MBM或DBM）以及糞便樣本（攝食後24小時的MBM/DBM）。通過ELISA分析樣本中抗H1N1血凝素（抗H1N1-HA）和抗H3N2神經氨酸酶（抗H3N2-NA）對免疫球蛋白A（IgA）、免疫球蛋白M（IgM）和免疫球蛋白G（IgG）等型的特异性。出生後8-9天，MBM組飼料和胃中流感特异性IgA相對豐度高於DBM組，21-22天差异無顯著性。在出生後的飼料和胃樣本中，MBM的抗流感特异性IgM均高於DBM。出生後兩個時期，MBM中抗流感A特异性IgG均高於DBM，但胃內容物無差异。胃消化降低了哺乳21-22天和8-9天時來自MBM和DBM的抗H3N2-NA-IgG，而其他抗流感A抗體在出生後兩個時間均未被消化。在DBM中補充抗流感A特异性抗體可能有助於降低流感病毒感染的風險。然而，誘導顯著保護作用所需的有效抗體劑量仍然未知。