The micropump components are an ele

The micropump components are an electrochemical bellows actuator, refillable drug reservoir, wireless inductive powering components, catheter, and check valve. By utilizing fabrication techniques from MEMS, or microelectromechanical systems, the actuation components are scalable to small animal models (including mice). The actuation is achieved through electrolysis, in which energy from the conversion of water to hydrogen and oxygen gases is harnessed to actively pump drug from the reservoir. This process generates low heat, requires low power consumption, and enables repeated dosing. The refillable drug reservoir can be sized to accommodate dosing needs for a specific animal model and application, and allows drug to be store adjacent to the target site in the body. A catheter directs the drug to the site. A check valve ensures accurate dosing without contamination or dilution of the drug in the reservoir. By using a wireless inductive powering scheme, the micropump operates without a battery and allows tetherless, unrestricted movement of the animal during the dosing. This is important, as stress from restraint and handling can significantly affect animal behavior and physiology. In addition, an integrated electrochemically-based dose tracking system is capable of real-time tracking and confirmation of delivery. With dose tracking, the micropump has closed-loop feedback for monitoring pump performance that can improve device reliability and increase patient safety.

結果 (繁體中文) 1:

微泵元件電化學波紋管作動器，可再充裝藥藏，無線感應供電元件，導管，並檢查閥。利用從 MEMS 或微電子機械系統的製造技術，驅動元件是可擴展到小動物模型 （包括小鼠）。驅動被通過電解法，從水庫水轉換為氫氣和氧氣的氣體的能量利用積極泵藥物。這一過程會產生低熱量、 要求低功率消耗，並使重複給藥。可再充裝藥藏可以調整大小，以容納加藥需要為一個特定的動物模型和應用程式，並允許商店毗鄰目標網站在體內的藥物。導管將定向到網站藥物。單向閥，確保無污染或稀釋的庫區藥物無計量準確。使用無線感應供電方案，泵運行無電池和加藥期間允許動物的移動，不受限制的運動。這是重要的因為從約束應力和處理可以顯著影響動物的行為和生理。此外，跟蹤系統集成基於電化學劑量是交貨的能夠即時跟蹤和確認。微型泵具有劑量跟蹤，閉環回饋監測泵的性能，可以提高設備的可靠性和增加病人的安全。

結果 (繁體中文) 2:

微型泵組件是一種電化學波紋管驅動器，可填充藥物儲存，無線感應供電元件，導管和止回閥。通過從MEMS或微機電系統利用製造技術，驅動組件擴展到小動物模型（包括小鼠）。致動是通過電解，其中能量從水到氫氣和氧氣的轉化是利用，以從儲存主動泵送藥物來實現的。這個過程產生熱量低，要求低功耗，並允許重複給藥。可再填充藥物儲存器的尺寸可以容納一個特定的動物模型和應用給藥的需要，並且允許藥物被存儲鄰接在體內的目標部位。的導管引導藥物到網站。止回閥確保沒有污染或容器中的藥物的稀釋精確的劑量。通過使用無線感應供電方案中，微型泵操作時無需電池，並允許給藥期間動物的tetherless，不受限制的運動。這一點很重要，因為從束縛和處理壓力會顯著影響動物行為和生理。此外，集成的基於電化學的劑量跟踪系統能夠實時跟踪和傳送的確認的。隨劑量跟踪，微型泵已閉環反饋用於監測泵的性能，可以提高設備的可靠性，並提高患者的安全。