Patients and Intervention Patients eligible for the study were initially assessed via anamnesis, physical examination, and evaluation of inspi- ratory muscle strength. Subsequently, these patients were randomly allocated to phase II of the CRP into two groups: a group subjected to CRP+IMT (GCR+IMT) followed the IMT protocol in addition to the combined training (aerobic and resistance training) and a group subjected to CRP (GCR) followed the combined training protocol and performed breathing exercises for 12 weeks. An RMS test was conduct- ed before and after the intervention, and the functional capac- ity and QoL were evaluated. All evaluations were conducted by investigators blinded to the allocation of patients into the intervention groups.