In the current study, athletes with a current injury exhibited HRQOL deficits as measured by the DPA summary components and FABQ. While those individuals participating injured reported better HRQOL than the athletes sidelined due to injury, deficits remained present. Clinicians should routinely monitor HRQOL postinjury and after return to activity to ensure complete, whole-person patient centered care and return to health. Although injury severity did not appear to impact HRQOL, it should be taken into consideration as athletes with severe injuries may experience prolonged participation restrictions. From the results of this study, it is clear that injury negatively influences HRQOL. While the exact contributors are unknown, it is imperative that clinicians assess HRQOL postinjury. Clinicians can use this information not only to better understand the impact of the injury on HRQOL, but also how effective their treatment is from the patient’s perspective. Future research should capture HRQOL outcomes prospectively to eliminate recall bias and account for other factors that may contribute to fluctuations. Furthermore, future investigations should extend HRQOL beyond the DPA and FABQ to evaluate the influence of injury on other outcomes that offer regional perceptions of impairment following injury. Identifying the patient’s perception of impairment will help facilitate evidence-based treatment and rehabilitation strategies that target the physical and psychosocial aspects of health.