Overall, while the pharmacological dysregulation of HsClpP shows great promise as a novel anticancer therapeutic approach, research is ongoing to optimize these drugs with respect to both their targeting specificity for HsClpP and their selectivity for cancer cells without damaging normal healthy ones, while maintaining other characteristics of the drugs that are crucial for their delivery to the targeted cells such as chemical stability, solubility, and cell permeability. Experimental efforts in this regard have often yielded mixed results, such that typically, chemical modifications may improve certain characteristics (e.g., drug potency) while diminishing others (e.g., aqueous solubility).