They recommend considering trimethoprim/sulfamethoxazole if the local resistance rate is less than 20% and fluoroquinolones if the resistance rate is less than 10% (Gupta 2011). The empiric regimen for complicated UTIs should also be guided by local susceptibility trends of uropathogens, and definitive regimens should be tailored according to susceptibility results,when available (Sobel 2014).