In the present study, we confirmed that IFNL3 minor genotype is associated with low LDL-C levels and with hepatic steatosis in HCV genotype-1 infection. The effect of IFNL3 genotype on hepatic steatosis remained significant after multivariate modeling. Moreover, a positive correlation seems to exist between the prevalence of IFNL3 minor genotype and the degree of hepatic steatosis. When IFNL3 genotype is included in the multivariate analysis, pretreatment serum cholesterol levels and/or hepatic steatosis is no longer associated with treatment response.