This research method belongs to mixed methods. The purpose of this study was to investigate how college students with English reading difficulties integrate their conceptions of and approaches to blended learning for enhancing their reading proficiency. A sample of 108 students was recruited – 54 students were assigned to the experimental group with blended learning and another 54 students to the control group with on-site instruction only. Data analysis includes paired samples t-test to analyze students’ progress in the pre- and post-tests and content analysis is conducted on students’ actions (recorded in the log files of the system, students’ on-site worksheets, and the interview responses.) Results of this study revealed that the blended learning was effective in enhancing students’ reading proficiency in the experimental group.