The Cu-Zn balance Khai et al. (2007) came out suggested a high risk of pollution including toxic elements and associated transfers through the food chain. (Holm et al., 2010).
We worried whether the medicines would bring dangers for aquatic organisms. But according to the previous research which experts have done, the environment risks can be reduced when we put dilution of pharmaceuticals into water. (Gros et al., 2010)