Over the ten decades, the development of novel natural compounds
and its derivatives with better medicinal virtue have greatly
attracted bioorganic chemists’ interest and become a hot research
topic in bioorganic chemistry, due to the success of taxol, vinblastine
and their related derivatives as anticancer agents [1e5]. In fact,
natural products have traditionally been good source of new medicinal
leads, and they play an important role in drug discovery,
especially in the area of cancer pharmacology, where the fraction of
the drugs derived from natural products amounts to 60% [6].