Trends in cancer incidence and mortality•Cancer is global problem, the global death rate due tocancer is estimated to be more than 6 million peopleannuall, over 22 million individuals have beendiagnosed with cancer worldwide.• The long-term downward trends in other causes ofdeath, primarily infectious and cardiovasculardiseases, more people live to an age when the risk ofdeveloping cancer becomes high.• Another major factor that affects the overallincidence of cancer is the change in the average age(long lifetime) of the population.