Overall, while the pharmacological dysregulation of HsClpP shows great promise as a novel anticancer therapeutic approach, research is ongoing to optimize these drugs with respect to both their targeting specificity for HsClpP and their selectivity for cancer cells without damaging normal healthy ones, while maintaining other characteristics of the drugs thatare crucial for their delivery to the targeted cells such as chemical stability, solubility, and cell permeability. Experimental efforts in this regard have often yielded mixed results,such that typically, chemical modifications may improve certain characteristics (e.g., drug potency) while diminishing others (e.g., aqueous solubility). Alternatively, efforts can bedirected at designing new drug formulation, such that optimization of compounds can be focused on refining the characteristics related to potency (e.g., target specificity and affinity), while issues related to its compatibility with physiological environments (e.g., aqueous solubility and delivery) can be solved through proper formulation.