The presence of an increased fibrotic processinvolves a possible role of TGF-β1 in the pathology ofdilated cardiomyopathy. Sanderson JE et al. [12] foundthat TGF-β1 plasma levels were two times higher inpatients who developed idiopathic dilated cardiomyopathy,compared with control groups, and Wenner CEand Yan S [13] showed that TGF-β1 is involved in theproliferation of mesenchymal cells such as fibroblasts,necessary for stroma formation in many organs