Therefore, the present study reexamined the feasibility and effectiveness of IOT for cognitive functioning and other outcomes including social functioning, intrinsic motivation, medication adherence, symptoms, and treatment satisfaction in patients with schizophrenia using a multicenter, randomized, controlled trial design. We hypothesized that IOT would be feasible for use in Japanese psychiatric hospitals settings and improve cognitive impairment as compared with GOT. Moreover, hypotheses included that other outcomes would be better for patients in IOT in comparison to those in GOT.